Stenosing Crohn’s disease patients display gut autophagy/oxidative stress imbalance

Stenosing Crohn’s disease patients display gut autophagy/oxidative stress imbalance

Abstract In this pilot study, we assessed the role of autophagy in Crohn’s Disease (CD), particularly in patients with a stenosing phenotype. Through the analysis of biopsied specimens from 36 patients, including 11 controls and 25 CD patients, categorized into inflammatory and stenosing groups, we...

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Main Authors: Leonardo Schirone, Maria Carla Di Paolo, Daniele Vecchio, Cristina Nocella, Alessandra D’Amico, Riccardo Urgesi, Lorella Pallotta, Gianfranco Fanello, Giuseppe Villotti, Maria Giovanna Graziani, Mariangela Peruzzi, Elena De Falco, Roberto Carnevale, Sebastiano Sciarretta, Giacomo Frati, Cristiano Pagnini
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Inflammatory Bowel Disease (IBD)
Autophagic Dysregulation
Reactive Oxygen Species (ROS)
Fibrostenotic Complications
Redox Homeostasis
Online Access:https://doi.org/10.1038/s41598-024-79308-z
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https://doi.org/10.1038/s41598-024-79308-z

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