KRAS Mutation in Serous Borderline Tumor of the Testis: Report of a Case and Review of the Literature
Ovarian-like epithelial tumors of the testis, including serous borderline tumors, are rare entities. We report the case of a 60-year-old man with a left intratesticular mass who had a radical orchidectomy. Histologically, the tumor was identical to the ovarian counterpart showing a well-delineated c...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Urology |
| Online Access: | http://dx.doi.org/10.1155/2020/5419707 |
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| author | Sarah Bouri Jean-Christophe Noël Xavier Catteau Walid Al Hajj Obeid Ilyas Svistakov Thierry Roumeguère Nicky D’Haene Sandrine Rorive |
| author_facet | Sarah Bouri Jean-Christophe Noël Xavier Catteau Walid Al Hajj Obeid Ilyas Svistakov Thierry Roumeguère Nicky D’Haene Sandrine Rorive |
| author_sort | Sarah Bouri |
| collection | DOAJ |
| description | Ovarian-like epithelial tumors of the testis, including serous borderline tumors, are rare entities. We report the case of a 60-year-old man with a left intratesticular mass who had a radical orchidectomy. Histologically, the tumor was identical to the ovarian counterpart showing a well-delineated cystic lesion characterized by intraluminal papillae. The papillae are lined by atypical cuboidal or ciliated cells and are associated with psammoma bodies. The tumor cells express cytokeratin 7 (CK7), cytokeratin 5-6 (CK5-6), cancer antigen 125 (CA125), estrogen (ER), progesterone (PR), Wilm’s tumor gene (WT1), paired box gene 8 (PAX8), Ber-EP4, and epithelial membrane antigen (EMA). The diagnosis of a serous borderline tumor of the testis was proposed. Mutation testing using next-generation sequencing showed a Q61K KRAS gene mutation. To the best of our knowledge, this is the second case report of a serous borderline tumor of the testis with a Q61K KRAS gene mutation. |
| format | Article |
| id | doaj-art-3ad69ec94f7a47be8b65abacec8b3554 |
| institution | Kabale University |
| issn | 2090-696X 2090-6978 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Urology |
| spelling | doaj-art-3ad69ec94f7a47be8b65abacec8b35542025-02-03T06:46:40ZengWileyCase Reports in Urology2090-696X2090-69782020-01-01202010.1155/2020/54197075419707KRAS Mutation in Serous Borderline Tumor of the Testis: Report of a Case and Review of the LiteratureSarah Bouri0Jean-Christophe Noël1Xavier Catteau2Walid Al Hajj Obeid3Ilyas Svistakov4Thierry Roumeguère5Nicky D’Haene6Sandrine Rorive7Department of Pathology, Erasme Hospital, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Pathology, Erasme Hospital, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Pathology, Erasme Hospital, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Urology, Erasme Hospital, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Urology, Erasme Hospital, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Urology, Erasme Hospital, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Pathology, Erasme Hospital, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Pathology, Erasme Hospital, Université Libre de Bruxelles, Brussels, BelgiumOvarian-like epithelial tumors of the testis, including serous borderline tumors, are rare entities. We report the case of a 60-year-old man with a left intratesticular mass who had a radical orchidectomy. Histologically, the tumor was identical to the ovarian counterpart showing a well-delineated cystic lesion characterized by intraluminal papillae. The papillae are lined by atypical cuboidal or ciliated cells and are associated with psammoma bodies. The tumor cells express cytokeratin 7 (CK7), cytokeratin 5-6 (CK5-6), cancer antigen 125 (CA125), estrogen (ER), progesterone (PR), Wilm’s tumor gene (WT1), paired box gene 8 (PAX8), Ber-EP4, and epithelial membrane antigen (EMA). The diagnosis of a serous borderline tumor of the testis was proposed. Mutation testing using next-generation sequencing showed a Q61K KRAS gene mutation. To the best of our knowledge, this is the second case report of a serous borderline tumor of the testis with a Q61K KRAS gene mutation.http://dx.doi.org/10.1155/2020/5419707 |
| spellingShingle | Sarah Bouri Jean-Christophe Noël Xavier Catteau Walid Al Hajj Obeid Ilyas Svistakov Thierry Roumeguère Nicky D’Haene Sandrine Rorive KRAS Mutation in Serous Borderline Tumor of the Testis: Report of a Case and Review of the Literature Case Reports in Urology |
| title | KRAS Mutation in Serous Borderline Tumor of the Testis: Report of a Case and Review of the Literature |
| title_full | KRAS Mutation in Serous Borderline Tumor of the Testis: Report of a Case and Review of the Literature |
| title_fullStr | KRAS Mutation in Serous Borderline Tumor of the Testis: Report of a Case and Review of the Literature |
| title_full_unstemmed | KRAS Mutation in Serous Borderline Tumor of the Testis: Report of a Case and Review of the Literature |
| title_short | KRAS Mutation in Serous Borderline Tumor of the Testis: Report of a Case and Review of the Literature |
| title_sort | kras mutation in serous borderline tumor of the testis report of a case and review of the literature |
| url | http://dx.doi.org/10.1155/2020/5419707 |
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