Profilin 1 induces drug resistance by downregulating CD138 expression via autophagy in multiple myeloma
Abstract Multiple myeloma (MM), a plasma cell-derived malignant hematological disease, is often treated with bortezomib, a highly effective first-generation proteasome inhibitor. However, resistance to bortezomib is a common occurrence. Profilin 1 (PFN1), a cytoskeleton-related gene known to promote...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-03-01
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| Series: | Discover Oncology |
| Online Access: | https://doi.org/10.1007/s12672-025-02036-x |
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