In vitro and in silico evaluation of fluorinated diphenylamine chalcone derivatives as potential antimalarial and anticancer agents

In vitro and in silico evaluation of fluorinated diphenylamine chalcone derivatives as potential antimalarial and anticancer agents

Abstract A series of novel diphenylamine fluorinated chalcone derivatives (B1–B10) were synthesized and characterized using 1H and 13C NMR, IR, and MS, and purity was determined using HPLC. The compounds were evaluated for their antimicrobial, antimalarial, and anticancer activities, with Chloramphe...

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Main Authors: Aviral Shah, Kathan Desai, Ajaykumar Bhanusali, Shikha Agrawal, Khushbu Patel, Nilesh Naik, Anuj Thakar, Hem Naik, Dilip Kanjariya, Naved Malek, Smita Jauhari, Yogesh Kadam, Bhavesh Patel, Ankit B. Shah
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Fluorinated diphenylamine Chalcones
In vitro biological evaluation
Methoxy functional group (-OCH3)
In Silico study
Online Access:https://doi.org/10.1038/s41598-025-04073-6
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https://doi.org/10.1038/s41598-025-04073-6

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