EDN1 and NTF3 in keloid pathogenesis: computational and experimental evidence as novel diagnostic biomarkers for fibrosis and inflammation

EDN1 and NTF3 in keloid pathogenesis: computational and experimental evidence as novel diagnostic biomarkers for fibrosis and inflammation

ObjectiveTo investigate the roles of oxidative stress-related differentially expressed genes (OSRDEGs) in keloid formation and explore their potential value in diagnosis and treatment.MethodsGene expression data from the GEO database, including GSE145725 and GSE44270 as training sets and GSE7890 as...

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Bibliographic Details
Main Authors: Hui Gong, Jing Liu, Nanji Chen, Hengguang Zhao, Bailin He, Hongpei Zhang, Wenping Wang, Yi Tian
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Genetics
Subjects:
keloid formation
oxidative stress
fibrosis
inflammation
immune response
MAPK
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1516451/full
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https://www.frontiersin.org/articles/10.3389/fgene.2025.1516451/full

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