Atomic-level investigation of KCNJ2 mutations associated with ventricular arrhythmic syndrome phenotypes

Atomic-level investigation of KCNJ2 mutations associated with ventricular arrhythmic syndrome phenotypes

Abstract KCNJ2 encodes the inward rectifying potassium channel (Kir2.1) that underlies I K1 which maintains the cardiac resting membrane potential and regulates excitability. Mutations in KCNJ2 have been linked to several clinical phenotypes associated with life-threatening ventricular arrhythmia an...

Full description

Saved in:
Bibliographic Details
Main Authors: Saba Munawar, Corey L. Anderson, Louise Reilly, Ryan Woltz, Yusra Sajid Kiani, Nipavan Chiamvimonvat, Lee L. Eckhardt
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
KCNJ2
Kir2.1
Inward rectifier current
Molecular modeling
Site-directed mutagenesis analysis
MD simulation
Online Access:https://doi.org/10.1038/s41598-025-95062-2
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-025-95062-2

Similar Items