Magnolol induces cell death through PI3K/Akt‐mediated epigenetic modifications boosting treatment of BRAF‐ and NRAS‐mutant melanoma

Magnolol induces cell death through PI3K/Akt‐mediated epigenetic modifications boosting treatment of BRAF‐ and NRAS‐mutant melanoma

Abstract Most BRAF‐mutant melanoma patients experience a fulminate relapse after several months of treatment with BRAF/MEK inhibitors. To improve therapeutic efficacy, natural plant‐derived compounds might be considered as potent additives. Here, we show that magnolol, a constituent of Magnolia offi...

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Bibliographic Details
Main Authors: Abdullah Al Emran, Brinda Reddy Chinna Chowdary, Farzana Ahmed, Heinz Hammerlindl, Antje Huefner, Nikolas K. Haass, Wolfgang Schuehly, Helmut Schaider
Format: Article
Language:English
Published: Wiley 2019-03-01
Series:Cancer Medicine
Subjects:
Akt
BRAF
histone mark
Magnolia officinalis
magnolol
melanoma
Online Access:https://doi.org/10.1002/cam4.1978
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https://doi.org/10.1002/cam4.1978

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