Incorporation and Repair of Epigenetic Intermediates as Potential Chemotherapy Agents

Incorporation and Repair of Epigenetic Intermediates as Potential Chemotherapy Agents

The incorporation of nucleoside analogs into DNA by polymerases, followed by their removal through base excision repair (BER), represents a promising strategy for cancer chemotherapy. In this study, we investigated the incorporation and cytotoxic effects of several nucleoside analogs—some of which a...

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Bibliographic Details
Main Authors: Jason L. Herring, Mark L. Sowers, James W. Conrad, Linda C. Hackfeld, Bruce Chang-Gu, Rahul Dilawari, Lawrence C. Sowers
Format: Article
Language:English
Published: MDPI AG 2025-08-01
Series:Molecules
Subjects:
chemotherapy
DNA
glioblastoma
epigenetic intermediates
trifluorothymidine
TFT
Online Access:https://www.mdpi.com/1420-3049/30/15/3239
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