Humoral correlates of protection against Mycobacterium tuberculosis following intravenous BCG vaccination in rhesus macaques

Humoral correlates of protection against Mycobacterium tuberculosis following intravenous BCG vaccination in rhesus macaques

Summary: Altering Bacille Calmette-Guérin (BCG) immunization from low-dose intradermal (i.d.) to high-dose intravenous (i.v.) vaccination provides a high level of protection against Mycobacterium tuberculosis (Mtb). In addition to strong T cell immunity, i.v. BCG drives robust humoral immune respons...

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Bibliographic Details
Main Authors: Edward B. Irvine, Patricia A. Darrah, Shu Wang, Chuangqi Wang, Ryan P. McNamara, Mario Roederer, Robert A. Seder, Douglas A. Lauffenburger, JoAnne L. Flynn, Sarah M. Fortune, Galit Alter
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:iScience
Subjects:
Health sciences
Immunology
Pathophysiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224023538
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http://www.sciencedirect.com/science/article/pii/S2589004224023538

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