Dysregulated lipids homeostasis disrupts CHAC1-mediated ferroptosis driving fibroblast growth factor receptor tyrosine kinase inhibitor AZD4547 resistance in gastric cancer

Dysregulated lipids homeostasis disrupts CHAC1-mediated ferroptosis driving fibroblast growth factor receptor tyrosine kinase inhibitor AZD4547 resistance in gastric cancer

Aims: This study investigates the mechanisms underlying acquired resistance to FGFR tyrosine kinase inhibitor (FGFR-TKI) in gastric cancer (GC), focusing on the interplay between ferroptosis and lipid metabolism of tumor cells. Methods: We constructed FGFR-TKI-resistant cell lines from GC cells. RNA...

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Main Authors: Jingwen Chen, Yedi Huang, Daocheng Zuo, Ruimin Shan, Songmao Li, Ran Li, Dong Hua, Qiang Zhan, Xudong Song, Yun Chen, Pei Ma, Ling Ma, Guoquan Tao, Yongqian Shu
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Redox Biology
Subjects:
Gastric cancer
FGFR-TKI resistance
Ferroptosis
CHAC1
Cholesterol metabolism
Lipidomics
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172500206X
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