Lactate modulates the function of myeloid-derived suppressor cells via Ten-Eleven-Translocation-2-mediated demethylation of glucocorticoid-inducible kinase 1 in lung cancer model

Lactate modulates the function of myeloid-derived suppressor cells via Ten-Eleven-Translocation-2-mediated demethylation of glucocorticoid-inducible kinase 1 in lung cancer model

BackgroundLactate has been shown to play an important immunosuppressive role in the tumor microenvironment (TME) and promote tumor progression through a variety of different mechanisms of action. Myeloid-derived suppressor cells (MDSCs) are important cells that play an immunosuppressive role in the...

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Bibliographic Details
Main Authors: Ying Chu, Hua Shen, Qiu Li, Bo Shen, Yan Zhang, Deqiang Wang, Wei Zhu, Shengjun Wang, Jie Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
lactate
MDSCs
TET2
SGK1
DNA methylation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1565993/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1565993/full

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