Dysbiosis-associated gut bacterium Ruminococcus gnavus varies at the strain level in its ability to utilize key mucin component sialic acid

Dysbiosis-associated gut bacterium Ruminococcus gnavus varies at the strain level in its ability to utilize key mucin component sialic acid

ABSTRACT Ruminococcus gnavus is a prevalent human gut commensal bacterium with known roles in intestinal mucus degradation, including by catabolism of the terminal mucin sugar sialic acid. While R. gnavus is not considered a pathogen, overabundance of this species is correlated with inflammatory bow...

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Bibliographic Details
Main Authors: Olga M. Sokolovskaya, Jasmina Uzunovic, Yutian Peng, Mikiko Okumura, Lingjue Mike Wang, Yuhui Zhou, Zijuan Lai, Elizabeth Skippington, Man-Wah Tan
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
Ruminococcus gnavus
sialic acid
2,7-anhydro-Neu5Ac
strain-level diversity
mucin glycans
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03090-24
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https://journals.asm.org/doi/10.1128/spectrum.03090-24

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