Structural information in therapeutic peptides: Emerging applications in biomedicine
Peptides are attracting a growing interest as therapeutic agents. This trend stems from their cost‐effectiveness and reduced immunogenicity, compared to antibodies or recombinant proteins, but also from their ability to dock and interfere with large protein–protein interaction surfaces, and their hi...
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | FEBS Open Bio |
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| Online Access: | https://doi.org/10.1002/2211-5463.13847 |
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| author | Valentín Iglesias Oriol Bárcenas Carlos Pintado‐Grima Michał Burdukiewicz Salvador Ventura |
| author_facet | Valentín Iglesias Oriol Bárcenas Carlos Pintado‐Grima Michał Burdukiewicz Salvador Ventura |
| author_sort | Valentín Iglesias |
| collection | DOAJ |
| description | Peptides are attracting a growing interest as therapeutic agents. This trend stems from their cost‐effectiveness and reduced immunogenicity, compared to antibodies or recombinant proteins, but also from their ability to dock and interfere with large protein–protein interaction surfaces, and their higher specificity and better biocompatibility relative to organic molecules. Many tools have been developed to understand, predict, and engineer peptide function. However, most state‐of‐the‐art approaches treat peptides only as linear entities and disregard their structural arrangement. Yet, structural details are critical for peptide properties such as solubility, stability, or binding affinities. Recent advances in peptide structure prediction have successfully addressed the scarcity of confidently determined peptide structures. This review will explore different therapeutic and biotechnological applications of peptides and their assemblies, emphasizing the importance of integrating structural information to advance these endeavors effectively. |
| format | Article |
| id | doaj-art-3a0ccd9dde104f90966f67d565ad1def |
| institution | Kabale University |
| issn | 2211-5463 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj-art-3a0ccd9dde104f90966f67d565ad1def2025-02-03T10:59:30ZengWileyFEBS Open Bio2211-54632025-02-0115225426810.1002/2211-5463.13847Structural information in therapeutic peptides: Emerging applications in biomedicineValentín Iglesias0Oriol Bárcenas1Carlos Pintado‐Grima2Michał Burdukiewicz3Salvador Ventura4Institut de Biotecnologia i de Biomedicina and Departament de Bioquímica i Biologia Molecular Universitat Autònoma de Barcelona Barcelona SpainInstitut de Biotecnologia i de Biomedicina and Departament de Bioquímica i Biologia Molecular Universitat Autònoma de Barcelona Barcelona SpainInstitut de Biotecnologia i de Biomedicina and Departament de Bioquímica i Biologia Molecular Universitat Autònoma de Barcelona Barcelona SpainInstitut de Biotecnologia i de Biomedicina and Departament de Bioquímica i Biologia Molecular Universitat Autònoma de Barcelona Barcelona SpainInstitut de Biotecnologia i de Biomedicina and Departament de Bioquímica i Biologia Molecular Universitat Autònoma de Barcelona Barcelona SpainPeptides are attracting a growing interest as therapeutic agents. This trend stems from their cost‐effectiveness and reduced immunogenicity, compared to antibodies or recombinant proteins, but also from their ability to dock and interfere with large protein–protein interaction surfaces, and their higher specificity and better biocompatibility relative to organic molecules. Many tools have been developed to understand, predict, and engineer peptide function. However, most state‐of‐the‐art approaches treat peptides only as linear entities and disregard their structural arrangement. Yet, structural details are critical for peptide properties such as solubility, stability, or binding affinities. Recent advances in peptide structure prediction have successfully addressed the scarcity of confidently determined peptide structures. This review will explore different therapeutic and biotechnological applications of peptides and their assemblies, emphasizing the importance of integrating structural information to advance these endeavors effectively.https://doi.org/10.1002/2211-5463.13847antimicrobial peptidespeptide drug developmentpeptide structurepeptidestherapeutic peptidestranslational medicine |
| spellingShingle | Valentín Iglesias Oriol Bárcenas Carlos Pintado‐Grima Michał Burdukiewicz Salvador Ventura Structural information in therapeutic peptides: Emerging applications in biomedicine FEBS Open Bio antimicrobial peptides peptide drug development peptide structure peptides therapeutic peptides translational medicine |
| title | Structural information in therapeutic peptides: Emerging applications in biomedicine |
| title_full | Structural information in therapeutic peptides: Emerging applications in biomedicine |
| title_fullStr | Structural information in therapeutic peptides: Emerging applications in biomedicine |
| title_full_unstemmed | Structural information in therapeutic peptides: Emerging applications in biomedicine |
| title_short | Structural information in therapeutic peptides: Emerging applications in biomedicine |
| title_sort | structural information in therapeutic peptides emerging applications in biomedicine |
| topic | antimicrobial peptides peptide drug development peptide structure peptides therapeutic peptides translational medicine |
| url | https://doi.org/10.1002/2211-5463.13847 |
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