From inflammation to healing: the crucial role of GPR91 activation and SDH inhibition in chronic diabetic wound recovery

From inflammation to healing: the crucial role of GPR91 activation and SDH inhibition in chronic diabetic wound recovery

Abstract Background Diabetic foot ulcers (DFU) typically exhibit impaired healing due to dysregulated re-epithelialization and excessive inflammation. Succinate, a key metabolic intermediate, is now understood to regulate inflammation through G Protein-Coupled Receptor 91 (GPR91) and succinate dehyd...

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Main Authors: Hengdeng Liu, Shixin Zhao, Hanwen Wang, Xuefeng He, Suyue Gao, Minmin Su, Miao Zhen, Shuying Chen, Lei Chen, Julin Xie
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Stem Cell Research & Therapy
Subjects:
Succinate metabolism
GPR91
SDH
M2 macrophages
EpSCs
Diabetic wounds
Online Access:https://doi.org/10.1186/s13287-025-04480-6
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https://doi.org/10.1186/s13287-025-04480-6

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