Imaging-validated correlates and implications of the pathophysiologic mechanisms of ageing-related cerebral large artery and small vessel diseases: a systematic review and meta-analysis

Abstract Background Cerebral large artery and small vessel diseases are considered substrates of neurological disorders. We explored how the mechanisms of neurovascular uncoupling, dysfunctional blood–brain-barrier (BBB), compromised glymphatic pathway, and impaired cerebrovascular reactivity (CVR)...

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Bibliographic Details
Main Authors: Joseph A. Ackah, Xuelong Li, Huixing Zeng, Xiangyan Chen
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Behavioral and Brain Functions
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Online Access:https://doi.org/10.1186/s12993-025-00274-1
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