LAG3 limits regulatory T cell proliferation in α-synuclein gut-to-brain transmission model

LAG3 limits regulatory T cell proliferation in α-synuclein gut-to-brain transmission model

Abstract Background Pathological α-synuclein (α-syn) can spread from the gut to the central nervous system (CNS), with CD4 + T cells playing a key role in this process. Lymphocyte activation gene 3 (LAG3) is involved in intestinal inflammation, regulates CD4 + T cell proliferation and function, and...

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Main Authors: Wei-Xin Kong, Zhi-Ling Zhang, Jin Li, Si Zhu, Chong Li, Xiao-Li Dong, Ting-Ting Gan, Di Hu, Feng-Chu Liang, Ping-Yi Xu, Wen-Yuan Guo
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Neuroinflammation
Subjects:
LAG3
Regulatory T cell
Parkinson's disease
Gut to brain transmission
Alpha-synuclein
Preformed fibril
Online Access:https://doi.org/10.1186/s12974-025-03502-7
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https://doi.org/10.1186/s12974-025-03502-7

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