Addressing treatment switching in the ALTA-1L trial with g-methods: exploring the impact of model specification

Abstract Background Treatment switching in randomized clinical trials introduces challenges in performing causal inference. Intention To Treat (ITT) analyses often fail to fully capture the causal effect of treatment in the presence of treatment switching. Consequently, decision makers may instead b...

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Bibliographic Details
Main Authors: Amani Al Tawil, Sean McGrath, Robin Ristl, Ulrich Mansmann
Format: Article
Language:English
Published: BMC 2024-12-01
Series:BMC Medical Research Methodology
Subjects:
Online Access:https://doi.org/10.1186/s12874-024-02437-6
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