Analysis of Sodium Chloride Intake and Treg/Th17 Lymphocytes in Healthy Individuals and Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus
We assessed different immune parameters in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) with low (LSI) and high (HSI) sodium intake. Thirty-eight patients with RA, thirty-seven with SLE, and twenty-eight healthy subjects were studied and classified as LSI or HSI. Le...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/9627806 |
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| author | Marlen Vitales-Noyola Esther Layseca-Espinosa Lourdes Baranda Carlos Abud-Mendoza Perla Niño-Moreno Adriana Monsiváis-Urenda Yvonne Rosenstein Roberto González-Amaro |
| author_facet | Marlen Vitales-Noyola Esther Layseca-Espinosa Lourdes Baranda Carlos Abud-Mendoza Perla Niño-Moreno Adriana Monsiváis-Urenda Yvonne Rosenstein Roberto González-Amaro |
| author_sort | Marlen Vitales-Noyola |
| collection | DOAJ |
| description | We assessed different immune parameters in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) with low (LSI) and high (HSI) sodium intake. Thirty-eight patients with RA, thirty-seven with SLE, and twenty-eight healthy subjects were studied and classified as LSI or HSI. Levels and suppressive function of CD4+CD25+Foxp3+ and CD4+CD69+Foxp3− Treg cells were determined by flow cytometry in blood samples. Levels and in vitro differentiation of Th17 cells were also assessed. Similar levels of CD4+CD25+Foxp3+ and CD4+CD69+Foxp3− Treg cells were observed in LSI and HSI patients or controls. However, a positive correlation was detected between sodium intake and levels of CD4+CD25+Foxp3+ Treg cells in SLE and a negative association between CD4+CD69+Foxp3− Treg cells and sodium intake in RA. No other significant associations were detected, including disease activity and sodium intake. Moreover, the suppressor activity of CD4+CD25+Foxp3+ and CD4+CD69+Foxp3− Treg cells was similar in LSI and HSI patients or controls. The levels and in vitro differentiation of Th17 cells were also similar in LSI and HSI individuals. Our results suggest that, in the population studied (Mexican mestizo), the level of sodium intake is not apparently associated with different relevant immune parameters in healthy subjects or patients with SLE or RA. |
| format | Article |
| id | doaj-art-399620b730d943e493d3cdaeb022d2f0 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-399620b730d943e493d3cdaeb022d2f02025-02-03T05:48:16ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/96278069627806Analysis of Sodium Chloride Intake and Treg/Th17 Lymphocytes in Healthy Individuals and Patients with Rheumatoid Arthritis or Systemic Lupus ErythematosusMarlen Vitales-Noyola0Esther Layseca-Espinosa1Lourdes Baranda2Carlos Abud-Mendoza3Perla Niño-Moreno4Adriana Monsiváis-Urenda5Yvonne Rosenstein6Roberto González-Amaro7Research Center for Health Sciences and Biomedicine, UASLP, 78210 San Luis Potosí, SLP, MexicoResearch Center for Health Sciences and Biomedicine, UASLP, 78210 San Luis Potosí, SLP, MexicoResearch Center for Health Sciences and Biomedicine, UASLP, 78210 San Luis Potosí, SLP, MexicoRegional Unit of Rheumatology and Osteoporosis, Hospital Central Dr. Ignacio Morones Prieto, 78210 San Luis Potosí, SLP, MexicoResearch Center for Health Sciences and Biomedicine, UASLP, 78210 San Luis Potosí, SLP, MexicoResearch Center for Health Sciences and Biomedicine, UASLP, 78210 San Luis Potosí, SLP, MexicoInstituto de Biotecnología, UNAM, 62210 Cuernavaca, MOR, MexicoResearch Center for Health Sciences and Biomedicine, UASLP, 78210 San Luis Potosí, SLP, MexicoWe assessed different immune parameters in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) with low (LSI) and high (HSI) sodium intake. Thirty-eight patients with RA, thirty-seven with SLE, and twenty-eight healthy subjects were studied and classified as LSI or HSI. Levels and suppressive function of CD4+CD25+Foxp3+ and CD4+CD69+Foxp3− Treg cells were determined by flow cytometry in blood samples. Levels and in vitro differentiation of Th17 cells were also assessed. Similar levels of CD4+CD25+Foxp3+ and CD4+CD69+Foxp3− Treg cells were observed in LSI and HSI patients or controls. However, a positive correlation was detected between sodium intake and levels of CD4+CD25+Foxp3+ Treg cells in SLE and a negative association between CD4+CD69+Foxp3− Treg cells and sodium intake in RA. No other significant associations were detected, including disease activity and sodium intake. Moreover, the suppressor activity of CD4+CD25+Foxp3+ and CD4+CD69+Foxp3− Treg cells was similar in LSI and HSI patients or controls. The levels and in vitro differentiation of Th17 cells were also similar in LSI and HSI individuals. Our results suggest that, in the population studied (Mexican mestizo), the level of sodium intake is not apparently associated with different relevant immune parameters in healthy subjects or patients with SLE or RA.http://dx.doi.org/10.1155/2018/9627806 |
| spellingShingle | Marlen Vitales-Noyola Esther Layseca-Espinosa Lourdes Baranda Carlos Abud-Mendoza Perla Niño-Moreno Adriana Monsiváis-Urenda Yvonne Rosenstein Roberto González-Amaro Analysis of Sodium Chloride Intake and Treg/Th17 Lymphocytes in Healthy Individuals and Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus Journal of Immunology Research |
| title | Analysis of Sodium Chloride Intake and Treg/Th17 Lymphocytes in Healthy Individuals and Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus |
| title_full | Analysis of Sodium Chloride Intake and Treg/Th17 Lymphocytes in Healthy Individuals and Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus |
| title_fullStr | Analysis of Sodium Chloride Intake and Treg/Th17 Lymphocytes in Healthy Individuals and Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus |
| title_full_unstemmed | Analysis of Sodium Chloride Intake and Treg/Th17 Lymphocytes in Healthy Individuals and Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus |
| title_short | Analysis of Sodium Chloride Intake and Treg/Th17 Lymphocytes in Healthy Individuals and Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus |
| title_sort | analysis of sodium chloride intake and treg th17 lymphocytes in healthy individuals and patients with rheumatoid arthritis or systemic lupus erythematosus |
| url | http://dx.doi.org/10.1155/2018/9627806 |
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