Hexokinase2-engineered T cells display increased anti-tumor function

Hexokinase2-engineered T cells display increased anti-tumor function

BackgroundT cells face significant metabolic challenges in the tumor microenvironment (TME), where cancer cells monopolize critical nutrients like glucose and amino acids. This metabolic competition supports tumor growth while impairing T-cell anti-tumor responses, partly by reducing glycolytic func...

Full description

Saved in:
Bibliographic Details
Main Authors: Raphaëlle Toledano Zur, Shiran Didi Zurinam, Maria Radman, Elia Funaro Balouka, Tatiana Borodianskiy-Shteinberg, Dieter Saur, Cyrille J. Cohen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
T-cells
cellular immunotherapy
immunometabolism
hexokinase 2
TCR
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1477929/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2025.1477929/full

Similar Items