Comparative chromatin accessibility upon BDNF stimulation delineates neuronal regulatory elements

Comparative chromatin accessibility upon BDNF stimulation delineates neuronal regulatory elements

Abstract Neuronal stimulation induced by the brain‐derived neurotrophic factor (BDNF) triggers gene expression, which is crucial for neuronal survival, differentiation, synaptic plasticity, memory formation, and neurocognitive health. However, its role in chromatin regulation is unclear. Here, using...

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Main Authors: Ignacio L Ibarra, Vikram S Ratnu, Lucia Gordillo, In‐Young Hwang, Luca Mariani, Kathryn Weinand, Henrik M Hammarén, Jennifer Heck, Martha L Bulyk, Mikhail M Savitski, Judith B Zaugg, Kyung‐Min Noh
Format: Article
Language:English
Published: Springer Nature 2022-08-01
Series:Molecular Systems Biology
Subjects:
enhancers
gene expression
neuronal stimulation
post‐mitotic neurons
transcription factors
Online Access:https://doi.org/10.15252/msb.202110473
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https://doi.org/10.15252/msb.202110473

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