USP14 and UCHL5 synergistically deubiquitinate PKCα and translocate NF-κB to promote the progression of anaplastic thyroid cancer

USP14 and UCHL5 synergistically deubiquitinate PKCα and translocate NF-κB to promote the progression of anaplastic thyroid cancer

Abstract Anaplastic thyroid carcinoma (ATC), an exceptionally aggressive and rare subtype of thyroid cancer, accounts for 1–2% of all thyroid cancers yet carries a high mortality rate, with a median survival time of less than one year. Despite significant advancements in in the field of thyroid canc...

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Main Authors: Song Zhang, Bing Han, Bo Jiang, Mengyu Chen, Deyang Mu, Qi Wang, Shu Sun, Tong Xu, Feifeng Song, Xinxin Ren, Zongfu Pan, Ping Huang, Minghua Ge
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07890-9
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https://doi.org/10.1038/s41419-025-07890-9

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