The NF-κB-SLC7A11 axis regulates ferroptosis sensitivity in inflammatory macrophages

The NF-κB-SLC7A11 axis regulates ferroptosis sensitivity in inflammatory macrophages

M1-polarized macrophages exhibit remarkable resistance to ferroptosis, a form of regulated cell death driven by excessive lipid peroxidation. Yet the underlying mechanisms remain to be defined. Through CRISPR-based functional screen of metabolic genes combining transcriptomics analysis, we herein id...

Full description

Saved in:
Bibliographic Details
Main Authors: Mengjie Yang, Xiaowei Chen, Xiran Hu, Hexiang Li, Hao Huang, Yingzhe Fang, Jue Jiang, Hudan Liu, Yuan Wang, Guoliang Qing
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Insight
Subjects:
Macrophage
Ferroptosis
SLC7A11
RELA
Immune metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2772892725000318
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2772892725000318

Similar Items