CD28-CD57+ T cells from head and neck cancer patients produce high levels of cytotoxic granules and type II interferon but are not senescent

CD28-CD57+ T cells from head and neck cancer patients produce high levels of cytotoxic granules and type II interferon but are not senescent

T lymphocytes expressing CD57 and lacking costimulatory receptors CD27/CD28 have been reported to accumulate with aging, chronic infection, and cancer. These cells are described as senescent, with inability to proliferate but enhanced cytolytic and cytokine-producing capacity. However, robust functi...

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Bibliographic Details
Main Authors: Brendan L.C. Kinney, Brianna Brammer, Vikash Kansal, Connor J. Parrish, Haydn T. Kissick, Yuan Liu, Nabil F. Saba, Zachary S. Buchwald, Mark W. El-Deiry, Mihir R. Patel, Brian J. Boyce, Azeem S. Kaka, Jennifer H. Gross, H. Michael Baddour, Amy Y. Chen, Nicole C. Schmitt
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:OncoImmunology
Subjects:
CD28
CD57
cellular senescence
costimulation
head and neck cancer
KLRG1
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2024.2367777
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https://www.tandfonline.com/doi/10.1080/2162402X.2024.2367777

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