Crosstalk with infant-derived Th17 cells, as well as exposure to IL-22 promotes maturation of intestinal epithelial cells in an enteroid model

Crosstalk with infant-derived Th17 cells, as well as exposure to IL-22 promotes maturation of intestinal epithelial cells in an enteroid model

IntroductionThe intestinal epithelium of human infants is developmentally immature compared to that of adults. Exactly how this immaturity affects key epithelial functions and their interactions with nearby immune cells remains an understudied area of research, partly due to limited access to non-di...

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Bibliographic Details
Main Authors: Zohreh Sharafian, Paula T. Littlejohn, Christina Michalski, James A. Sousa, Janelle Cheung, Mariana Hill, Hannah Piper, Kevan Jacobson, Pascal M. Lavoie, Joannie M. Allaire, Bruce A. Vallance
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
IL22
Th17
enteroid models
infant
neonate
RNAseq
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1582688/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1582688/full

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