Downstream transcription promotes human recurrent CNV associated AT-rich sequence mediated genome rearrangements in yeast

Downstream transcription promotes human recurrent CNV associated AT-rich sequence mediated genome rearrangements in yeast

Summary: AT-rich sequence can cause structure variants such as translocations and its instability can be accelerated by replication stresses. When human 16p11.2 or 22q11.2 recurrent copy number variant (reCNV) associated AT-rich sequence was inserted upstream GAL1 promoter in yeast genome, we found...

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Bibliographic Details
Main Authors: Feng-Yun Xie, Xiao-Guohui Zhang, Juan Chen, Xin Xu, Sen Li, Tian-Jin Xia, Lei-Ning Chen, Shen Yin, Xiang-Hong Ou, Jun-Yu Ma
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:iScience
Subjects:
Properties of biomolecules
Techniques in genetics
Molecular genetics
Model organism
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224027354
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