Retrotransposon methylation profiles and survival in Black women with high-grade serous ovarian carcinoma

Retrotransposon methylation profiles and survival in Black women with high-grade serous ovarian carcinoma

Abstract Introduction Retrotransposons (REs) constitute nearly half of the genome and include long terminal repeat (LTR) elements, Long INterspersed Elements (LINE), and Short INterspersed Elements (SINE). REs are typically silenced in somatic tissues via DNA methylation but can be reactivated throu...

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Main Authors: Christelle Colin-Leitzinger, Katherine A. Lawson-Michod, Courtney E. Johnson, Irma M. Vlasac, Sean Yoder, Tania Mesa, Dana Roeber, Chad Huff, Michelle A. T. Hildebrandt, Kristin Haller, Anthony J. Alberg, Elisa V. Bandera, Melissa Bondy, Michele L. Cote, Theresa Hastert, Edward S. Peters, Paul D. Terry, Andrew B. Lawson, Andrew Berchuck, Brooke L. Fridley, Jing-Yi Chern, Jennifer A. Doherty, Jeffrey R. Marks, Joellen M. Schildkraut, Brock C. Christensen, Lucas A. Salas, Lauren C. Peres
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Clinical Epigenetics
Online Access:https://doi.org/10.1186/s13148-025-01942-9
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https://doi.org/10.1186/s13148-025-01942-9

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