miR-107 represses DMPK and is sequestered by CUG repeats triggering the MSI2/miR-7 pathogenesis axis in myotonic dystrophy

miR-107 represses DMPK and is sequestered by CUG repeats triggering the MSI2/miR-7 pathogenesis axis in myotonic dystrophy

Myotonic dystrophy type 1 (DM1) is a multisystem genetic disorder characterized by muscle disease, including muscle atrophy partially originating from excessive autophagy. We have previously demonstrated that excessive Musashi-2 (MSI2) repressed the biogenesis of miR-7, which derepressed autophagy,...

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Main Authors: N. Moreno, M. Sabater-Arcis, J. Espinosa-Espinosa, L. Mulet-Rivero, E. García-España, J. González-García, D. Seoane-Miraz, M.J.A. Wood, M.A. Varela, J. Ohana, T. Sevilla, M. Perez Alonso, A. Bargiela, R. Artero
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
miR-107
CUG repeats
DMPK
MSI2
DM1
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253125001386
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