Genomic analysis and therapeutic efficacy evaluation of bacteriophage PK2420 for pneumonia caused by hypervirulent Klebsiella pneumoniae (K20 serotype)

Genomic analysis and therapeutic efficacy evaluation of bacteriophage PK2420 for pneumonia caused by hypervirulent Klebsiella pneumoniae (K20 serotype)

ABSTRACT Hypervirulent Klebsiella pneumoniae (hvKp) strains are increasingly recognized for their aggressive nature, which leads to severe clinical outcomes. The emergence of multidrug-resistant strains constitutes a substantial challenge for clinical management. Phage therapy offers a potential sol...

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Main Authors: Jinfeng Chen, Junxia Feng, Xiaohu Cui, Lijuan Huang, Bing Du, Yuyan Xia, Guanhua Xue, Yanling Feng, Yuehua Ke, Hanqing Zhao, Jinghua Cui, Chao Yan, Lin Gan, Zheng Fan, Tongtong Fu, Ziying Xu, Yang Yang, Zihui Yu, Shuo Zhao, Zhen Wang, Yiming Kong, Boyi Jiang, Mingxuan Wang, Mengyao Ling, Jing Yuan
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mSystems
Subjects:
hypervirulent Klebsiella pneumoniae
K20 serotype
bacteriophage therapy
Online Access:https://journals.asm.org/doi/10.1128/msystems.01632-24
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https://journals.asm.org/doi/10.1128/msystems.01632-24

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