Molecular subtyping of stage I lung adenocarcinoma via molecular alterations in pre-invasive lesion progression

Molecular subtyping of stage I lung adenocarcinoma via molecular alterations in pre-invasive lesion progression

Abstract Background Patients with adenocarcinoma in situ (AIS) and minimally invasive (MIA) lung adenocarcinoma (LUAD) are curable by surgery, whereas 20% stage I patients die within five years after surgery. We hypothesize that poor-prognosis stage I patients may exhibit key molecular characteristi...

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Main Authors: Jun Shang, He Jiang, Yue Zhao, Jingcheng Yang, Yicong Lin, Naixin Zhang, Luyao Ren, Qingwang Chen, Ying Yu, Leming Shi, Yuan Li, Haiquan Chen, Yuanting Zheng
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Translational Medicine
Subjects:
Lung adenocarcinoma
Pre/minimally invasive
Molecular subtypes
Prognosis
COL11A1
THBS2
Online Access:https://doi.org/10.1186/s12967-025-06316-6
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https://doi.org/10.1186/s12967-025-06316-6

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