A cytidine deaminase-like protein modulates pyrimidine nucleotide homeostasis in Trypanosoma brucei

A cytidine deaminase-like protein modulates pyrimidine nucleotide homeostasis in Trypanosoma brucei

Abstract Pyrimidine nucleotide homeostasis is critical for DNA replication and cell viability, yet its regulation in Trypanosoma brucei, the causative agent of African trypanosomiasis, remains poorly understood. Here, we characterize a T. brucei cytidine deaminase-like protein (TbCDA-like), a kineto...

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Main Authors: Ana Moro-Bulnes, Cristina Bosch-Navarrete, Pablo Antequera-Parrilla, Santiago Castanys, Antonio E. Vidal, Luis Miguel Ruiz-Pérez, Guiomar Pérez-Moreno, Dolores González-Pacanowska
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Pyrimidine metabolism
Cytidine deaminase
Trypanosoma brucei
Nucleotide pools
DNA integrity
Stress granules
Online Access:https://doi.org/10.1038/s41598-025-00942-2
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https://doi.org/10.1038/s41598-025-00942-2

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