Renal organic anion transporter 1: clinical relevance and the underlying mechanisms in chronic kidney disease

Abstract Organic anion transporter 1 (OAT1), primarily found in the renal proximal tubule, is essential for the excretion of various uremic toxins that contribute to the onset and progression of chronic kidney disease (CKD). OAT1 also plays a vital role in the remote sensing and signaling network, f...

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Bibliographic Details
Main Authors: Changfang You, Jianchun Guo, Yunhao Xun
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Nephrology
Subjects:
Online Access:https://doi.org/10.1186/s12882-025-03974-y
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