Iron single atom enzyme-mediated hydrogen sulfide delivery amplifies reactive oxygen species cascade to induce ferroptosis susceptibility

Iron single atom enzyme-mediated hydrogen sulfide delivery amplifies reactive oxygen species cascade to induce ferroptosis susceptibility

Lipid peroxidation (LPO) represents one of the most deleterious processes contributing to ferroptosis susceptibility. However, the tumor microenvironment is often characterized by an overproduction of endogenous glutathione (GSH) and reactive oxygen species (ROS)-scavenging enzymes, which limit the...

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Bibliographic Details
Main Authors: Xuegang Niu, Penghui Wei, Mingtao Zhu, Hongjia Zheng, Dezhi Kang, Qianxi Chen, Fuxiang Chen, Yiping Li, Rong Xie, Yang Zhu, Dengliang Wang
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Materials Today Bio
Subjects:
Single atom enzyme
Hydrogen sulfide
Ferroptosis
Catalytic therapy
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425007549
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