Placental growth factor modulates endothelial NO production and exacerbates experimental hepatopulmonary syndrome

Placental growth factor modulates endothelial NO production and exacerbates experimental hepatopulmonary syndrome

Background & Aims: Hepatopulmonary syndrome (HPS) results from portal hypertension, with or without cirrhosis, and is marked by pulmonary vascular dilations leading to severe hypoxemia. Although placental growth factor (PlGF) is important for vascular growth and endothelial function, its rol...

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Main Authors: Fabien Robert, Feriel Benchenouf, My Ngoc Ha, Alessandra Cuomo, Mina Ottaviani, Maxime Surbier, Raphaël Thuillet, Corinne Normand, Florent Dumont, Céline Verstuyft, Frederic Fiore, Frederic Guinut, Marc Humbert, Audrey Coilly, Emmanuel Gonzales, Olivier Sitbon, Ly Tu, Christophe Guignabert, Laurent Savale
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:JHEP Reports
Subjects:
Liver cirrhosis
Portal hypertension
Pulmonary endothelial dysfunction
Partial portal vein ligation
Common bile duct ligation
Intrapulmonary vascular dilations
Online Access:http://www.sciencedirect.com/science/article/pii/S258955592400301X
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