Downregulated <i>ALDH2</i> Contributes to Tumor Progression and Targeted Therapy Resistance in Human Metastatic Melanoma Cells

Downregulated <i>ALDH2</i> Contributes to Tumor Progression and Targeted Therapy Resistance in Human Metastatic Melanoma Cells

Aldehyde dehydrogenase 2 (ALDH2) is a crucial detoxifying enzyme that eliminates toxic aldehydes. ALDH2 deficiency has been linked to various human diseases, including certain cancers. We have previously reported <i>ALDH2</i> downregulation in human melanoma tissues. Here, we further inv...

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Bibliographic Details
Main Authors: Zili Zhai, Takeshi Yamauchi, Karenna Sandoval, Kira Villarreal, Man Wai Charlotte Kwong, Emily J. Swanson, Aik Choon Tan, Mayumi Fujita
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
acetaldehyde
aldehyde dehydrogenase 2
drug resistance
MAPK/ERK
melanoma
targeted therapy
Online Access:https://www.mdpi.com/2073-4409/14/12/913
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