PTPRO represses breast cancer lung metastasis by inhibiting the JAK2-YAP axis

PTPRO represses breast cancer lung metastasis by inhibiting the JAK2-YAP axis

Abstract Lung metastasis is the primary cause of breast cancer-related mortality. Protein tyrosine phosphatases such as PTPRO are important in cancer progression. However, the role and underlying mechanisms of PTPRO in breast cancer lung metastasis are largely unknown. The function of PTPRO in breas...

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Main Authors: Xiao Xiong, Jingfang Liu, Xiaotong Wu, Zhimeng Yao, Yuhua Meng, Shuang Liu, Yexi Chen, Hongzheng Ren, Shegan Gao, Xiaofu Qiu, Hao Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Breast cancer
Lung metastasis
Epithelial‒mesenchymal transition
Tyrosine dephosphorylation
JAK2‒YAP pathway
Online Access:https://doi.org/10.1038/s41598-025-91341-0
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https://doi.org/10.1038/s41598-025-91341-0

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