Dexmedetomidine protects against N-Nitrosodiethylamine induced acute hepatic damage by modulating autophagy and apoptosis through SIRT1

Dexmedetomidine protects against N-Nitrosodiethylamine induced acute hepatic damage by modulating autophagy and apoptosis through SIRT1

Abstract Purpose Dexmedetomidine (DEX) has been extensively studied for its protective effects on multiple organs, primarily attributed to its anti-inflammatory and anti-apoptotic properties. However, the molecular mechanisms underlying its effects in acute hepatic damage induced by N-Nitrosodiethyl...

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Bibliographic Details
Main Authors: Ruixin Wu, Sailan Tang, Aoxue Xu, Qi Xue, Shuwen He, Qizhi Liao, Chanjuan Chen, Dachen Zhou, Xianwen Hu, Nianliang Zhang, Gang Li, Ye Zhang, Chunxia Huang
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Anesthesiology and Perioperative Science
Subjects:
Dexmedetomidine
Acute hepatic damage
SIRT1
Autophagy
Online Access:https://doi.org/10.1007/s44254-025-00113-6
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https://doi.org/10.1007/s44254-025-00113-6

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