DNA methylation and immune evasion in triple-negative breast cancer: challenges and therapeutic opportunities

DNA methylation and immune evasion in triple-negative breast cancer: challenges and therapeutic opportunities

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by the lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Chemotherapy remains the primary treatment option, yet TNBC frequently develops resista...

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Bibliographic Details
Main Authors: Wen-yu Cai, Xin-xian Cai, Yi-ran Fei, Rui Ye, Ding-ming Song, Dan Hu, Wan-wan Zhang, Ming-fei Xia, Xiao-xiao Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Oncology
Subjects:
triple-negative breast cancer
DNA methylation inhibitors
immune checkpoint inhibitors
immune evasion
epigenetic therapy
personalized medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1534055/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1534055/full

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