A model of a MAPK•substrate complex in an active conformation: a computational and experimental approach.

The mechanisms by which MAP kinases recognize and phosphorylate substrates are not completely understood. Efforts to understand the mechanisms have been compromised by the lack of MAPK-substrate structures. While MAPK-substrate docking is well established as a viable mechanism for bringing MAPKs and...

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Bibliographic Details
Main Authors: Sunbae Lee, Mangalika Warthaka, Chunli Yan, Tamer S Kaoud, Andrea Piserchio, Ranajeet Ghose, Pengyu Ren, Kevin N Dalby
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0018594&type=printable
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