Reposition of lenalidomide as a radiation protector based on LINCS gene expression signatures and its preclinical validation

Reposition of lenalidomide as a radiation protector based on LINCS gene expression signatures and its preclinical validation

Abstract Ionizing radiation induces DNA damage and impairs genomic integrity, leading to cell death and tissue injuries or carcinogenesis. Medical radiation protectors are essential and necessary. However, there are limited radioprotectors in clinics, which can’t meet the growing demand for counteri...

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Bibliographic Details
Main Authors: Qi Huang, Xiaoyao Yin, Hua Guan, Xin Huang, Bo Huang, Dafei Xie, Pingkun Zhou
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Lenalidomide
Drug reposition
Radioprotection
Immunoregulation
LINCS
Enrichment score
Online Access:https://doi.org/10.1038/s41598-025-97653-5
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https://doi.org/10.1038/s41598-025-97653-5

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