Myogenic nano-adjuvant for orthopedic-related sarcopenia via mitochondrial homeostasis modulation in macrophage-myosatellite metabolic crosstalk

Myogenic nano-adjuvant for orthopedic-related sarcopenia via mitochondrial homeostasis modulation in macrophage-myosatellite metabolic crosstalk

Abstract The decline in skeletal muscle mass and muscle strength linked to aging, also known as sarcopenia, is strongly associated with disability, traumatic injury, and metabolic disease in patients. Meanwhile, sarcopenia increases the risk of adverse orthopedic perioperative complications includin...

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Main Authors: Xudong Zhang, Peng Zhang, Yunliang Zhu, Jiaqing Lou, Peng Wu, Yingjie Wang, Zhengxi Wang, Quan Liu, Baoliang Lu, Qianming Li, Jiawei Mei, Chen Zhu, Wanbo Zhu, Xianzuo Zhang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Nanobiotechnology
Subjects:
Orthopedic-related sarcopenia
Systematic sarcopenia
Myogenic nano-adjuvant
Mitochondrial homeostasis
Metabolic crosstalk
Online Access:https://doi.org/10.1186/s12951-025-03480-1
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https://doi.org/10.1186/s12951-025-03480-1

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