PAICS-Driven Purine Biosynthesis and Its Prognostic Implications in Lung Adenocarcinoma: A Novel Risk Stratification Model and Therapeutic Insights

PAICS-Driven Purine Biosynthesis and Its Prognostic Implications in Lung Adenocarcinoma: A Novel Risk Stratification Model and Therapeutic Insights

Background: Lung adenocarcinoma is the most common NSCLC and is associated with metabolic dysregulation. Purine biosynthesis, regulated by PAICS, plays a key role in tumor progression and therapy resistance. Methods: We focused on LUAD using pan-cancer and KEGG enrichment analyses. TCGA-LUAD and thr...

Full description

Saved in:
Bibliographic Details
Main Authors: Jinhui Liu, Qi-An Chen, Yannan Yang, Lin Zhang, Weihao Lin, Yuheng Hong, Yibo Gao
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Current Issues in Molecular Biology
Subjects:
lung adenocarcinoma
purine metabolism
prognostic model
PAICS
tumor microenvironment
Online Access:https://www.mdpi.com/1467-3045/47/5/366
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/1467-3045/47/5/366

Similar Items