Deep sphingolipidomic and metabolomic analyses of ceramide synthase 2 null mice reveal complex pathway-specific effects

Deep sphingolipidomic and metabolomic analyses of ceramide synthase 2 null mice reveal complex pathway-specific effects

The sphingolipidome contains thousands of structurally distinct sphingolipid (SL) species. This enormous diversity is generated by the combination of different long-chain bases (LCBs), N-acyl chains and head groups. In mammals, LCBs are N-acylated with different fatty acids (from C14 to C32, with di...

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Main Authors: Jeongah Oh, Sneha Muralidharan, Qing Zhao, Johannes Scholz, Iris D. Zelnik, Shani Blumenreich, Tammar Joseph, Tamir Dingjan, Pradeep Narayanaswamy, Hyungwon Choi, Heiko Hayen, Federico Torta, Anthony H. Futerman
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Journal of Lipid Research
Subjects:
mass spectrometry
sphingolipids
ceramide
cerebrosides
sphingomyelin
glycosphingolipids
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227525000926
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