High Content Imaging and Analysis Enable Quantitative In Situ Assessment of CYP3A4 Using Cryopreserved Differentiated HepaRG Cells

High-throughput imaging-based hepatotoxicity studies capable of analyzing individual cells in situ hold enormous promise for drug safety testing but are frequently limited by a lack of sufficient metabolically competent human cells. This study examined cryopreserved HepaRG cells, a human liver cell...

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Bibliographic Details
Main Authors: Aarati R. Ranade, Melinda S. Wilson, Amy M. McClanahan, Andrew J. Ball
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:Journal of Toxicology
Online Access:http://dx.doi.org/10.1155/2014/291054
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