In vitro and in vivo characterization of wild type BMP9 and a non-osteogenic variant in models of pulmonary arterial hypertension.

In vitro and in vivo characterization of wild type BMP9 and a non-osteogenic variant in models of pulmonary arterial hypertension.

Endothelial dysfunction and the resulting vascular remodeling are hallmarks of pulmonary hypertension, a debilitating disease of high arterial pressure in the lungs and the right side of the heart. Mutations in the BMPR2 signaling pathway are associated with the development of pulmonary arterial hyp...

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Main Authors: Tobias G Schips, Karl W Kavalkovich, Lai-Ming Yung, Salam Ibrahim, Makhosi Edmondson, Zhigang Hong, Chin-Hu Huang, Simon Hinke, Xinkang Wang, Andrea R Nawrocki, Annmarie Winkis, Jinquan Luo, Iman Farasat, Brian Geist, Yang Wang, Russell Bialecki, Jey R Jeyaseelan, David R Bauman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0329089
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https://doi.org/10.1371/journal.pone.0329089

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