Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases
Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies. Both basic cell migration and migration towards chemotactic stimulus consist of changes in cell polarity and cytoskeletal rearrangement,...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/9621724 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558512831463424 |
|---|---|
| author | D. Dreymueller K. Theodorou M. Donners A. Ludwig |
| author_facet | D. Dreymueller K. Theodorou M. Donners A. Ludwig |
| author_sort | D. Dreymueller |
| collection | DOAJ |
| description | Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies. Both basic cell migration and migration towards chemotactic stimulus consist of changes in cell polarity and cytoskeletal rearrangement, cell detachment from, invasion through, and reattachment to their neighboring cells, and numerous interactions with the extracellular matrix. The different steps of immune cell, tissue cell, or cancer cell migration are tightly coordinated in time and place by growth factors, cytokines/chemokines, adhesion molecules, and receptors for these ligands. This review describes how a disintegrin and metalloproteinases interfere with several steps of cell migration, either by proteolytic cleavage of such molecules or by functions independent of proteolytic activity. |
| format | Article |
| id | doaj-art-3844bdc201924ef6b9e18a96dd2ec5c3 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3844bdc201924ef6b9e18a96dd2ec5c32025-02-03T01:32:12ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/96217249621724Fine Tuning Cell Migration by a Disintegrin and MetalloproteinasesD. Dreymueller0K. Theodorou1M. Donners2A. Ludwig3Institute of Pharmacology and Toxicology, Uniklinik RWTH Aachen, Aachen, GermanyDepartment of Pathology, Maastricht University, LK Maastricht, NetherlandsDepartment of Pathology, Maastricht University, LK Maastricht, NetherlandsInstitute of Pharmacology and Toxicology, Uniklinik RWTH Aachen, Aachen, GermanyCell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies. Both basic cell migration and migration towards chemotactic stimulus consist of changes in cell polarity and cytoskeletal rearrangement, cell detachment from, invasion through, and reattachment to their neighboring cells, and numerous interactions with the extracellular matrix. The different steps of immune cell, tissue cell, or cancer cell migration are tightly coordinated in time and place by growth factors, cytokines/chemokines, adhesion molecules, and receptors for these ligands. This review describes how a disintegrin and metalloproteinases interfere with several steps of cell migration, either by proteolytic cleavage of such molecules or by functions independent of proteolytic activity.http://dx.doi.org/10.1155/2017/9621724 |
| spellingShingle | D. Dreymueller K. Theodorou M. Donners A. Ludwig Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases Mediators of Inflammation |
| title | Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases |
| title_full | Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases |
| title_fullStr | Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases |
| title_full_unstemmed | Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases |
| title_short | Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases |
| title_sort | fine tuning cell migration by a disintegrin and metalloproteinases |
| url | http://dx.doi.org/10.1155/2017/9621724 |
| work_keys_str_mv | AT ddreymueller finetuningcellmigrationbyadisintegrinandmetalloproteinases AT ktheodorou finetuningcellmigrationbyadisintegrinandmetalloproteinases AT mdonners finetuningcellmigrationbyadisintegrinandmetalloproteinases AT aludwig finetuningcellmigrationbyadisintegrinandmetalloproteinases |