RBM10 deficiency promotes brain metastasis by modulating sphingolipid metabolism in a BBB model of EGFR mutant lung adenocarcinoma

RBM10 deficiency promotes brain metastasis by modulating sphingolipid metabolism in a BBB model of EGFR mutant lung adenocarcinoma

Abstract Background Brain metastasis significantly contributes to the failure of targeted therapy in patients with epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma (LUAD). Reduced expression of RNA-binding motif protein 10 (RBM10) is associated with brain metastasis in these patie...

Full description

Saved in:
Bibliographic Details
Main Authors: Gang Xu, Bo An, Ruqiong Wang, Bo Pan, Huiting Hao, Xingmei Ren, Zihan Jing, Weitong Gao, Yajie Li, Yan Jin, Enguang Lin, Lihua Shang, Dexin Jia, Yan Yu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Brain metastasis
RBM10
Lung adenocarcinoma
Sphingolipid metabolism
BBB
Online Access:https://doi.org/10.1186/s13046-025-03347-1
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13046-025-03347-1

Similar Items