Behavioral assessment and gene expression changes in a mouse model with dysfunctional STAT1 signaling

Behavioral assessment and gene expression changes in a mouse model with dysfunctional STAT1 signaling

Abstract Background Signal transduction via the Signal Transducer and Activator of Transcription 1 (STAT1) pathway is indispensable for mediating the intracellular effects of interferon-α (IFN-α), interferon-γ (IFN-γ) and other cytokines in the brain and, thereby, crucial for antiviral and antibacte...

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Main Authors: Luca Büschgens, Nina Hempel, Aditi Methi, Andre Fischer, Nele Siering, Lars Piepkorn, Olaf Jahn, Thomas Meyer, Oliver Wirths
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cell Communication and Signaling
Subjects:
STAT signaling
Interferon signaling
Gene expression
Proteome analysis
Behavior
Mice
Online Access:https://doi.org/10.1186/s12964-025-02313-w
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https://doi.org/10.1186/s12964-025-02313-w

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