Activating Effect of Benzbromarone, a Uricosuric Drug, on Peroxisome Proliferator-Activated Receptors

Benzbromarone, a uricosuric drug, reportedly causes hepatic hypertrophy accompanied by proliferation of peroxisomes in rats. To elucidate the mechanisms underlying induction of peroxisome proliferation by benzbromarone, we examined binding affinity for peroxisome proliferator-activated receptor α (P...

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Bibliographic Details
Main Authors: Chiyoko Kunishima, Ikuo Inoue, Toshihiro Oikawa, Hiromu Nakajima, Tsugikazu Komoda, Shigehiro Katayama
Format: Article
Language:English
Published: Wiley 2007-01-01
Series:PPAR Research
Online Access:http://dx.doi.org/10.1155/2007/36092
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