Insights into the role of hnRNPK in spermatogenesis via the piRNA pathway

Insights into the role of hnRNPK in spermatogenesis via the piRNA pathway

Abstract Deletion of hnRNPK in mouse spermatogonia leads to male sterility due to arrest permatogenesis, yet the underlying molecular mechanisms remain elusive. This study investigated the testicular proteome on postnatal day 28 (P28) to elucidate the infertility associated with Hnrnpk deficiency, i...

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Main Authors: Haixia Xu, Jiahua Guo, Yueru Huang, Mengjia Zhang, Yuxi Wang, Lianren Xia, Xiaofang Cheng, Tiantian Meng, Ruijie Hao, Xuefeng Wei, Cencen Li, Pengpeng Zhang, Yongjie Xu
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
hnRNPK
Proteomics
Conditional knock-out mice
piRNA pathway
Translational regulation
Spermatogenesis
Online Access:https://doi.org/10.1038/s41598-025-91081-1
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https://doi.org/10.1038/s41598-025-91081-1

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