Bone, dentin and cementum differentially influence the differentiation of osteoclast-like cells

Bone, dentin and cementum differentially influence the differentiation of osteoclast-like cells

Abstract Our aim was to investigate how different oral hard tissues determine the differentiation of osteoclast-like cells. Murine macrophage cells were stimulated for 12 day with RANKL and M-CSF on dentin slices. Morphological changes of cells and hard tissues were examined by electron microscopy a...

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Bibliographic Details
Main Authors: Annika Both, Ghosn Ibrahim, Jana Marciniak, Birgit Rath-Deschner, Erika Calvano Küchler, Christian Kirschneck, Lina Gölz, Andreas Jäger, Svenja Beisel-Memmert
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Orthodontic root resorption
Osteoclast differentiation
CXCL2
IGF-1
GDF15
HSPA1b
Online Access:https://doi.org/10.1038/s41598-025-04874-9
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https://doi.org/10.1038/s41598-025-04874-9

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